A recombinant adenovirus comprising a chimeric penton base protein, which includes a nonpenton base sequence, and a therapeutic gene, a method of gene therapy involving the use of such adenovirus, and adenoviral transfer vectors for the generation of such recombinant adenovirus are provided. ...http://www.google.es/patents/US5731190?utm_source=gb-gplus-sharePatente US5731190 - Penton base protein and methods of using same