Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant....http://www.google.es/patents/US6239116?utm_source=gb-gplus-sharePatente US6239116 - Immunostimulatory nucleic acid molecules