The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation...http://www.google.es/patents/US6159686?utm_source=gb-gplus-sharePatente US6159686 - Up-converting reporters for biological and other assays
Up-converting reporters for biological and other assays