The present invention provides chemically modified siRNA molecules and methods of using such siRNA molecules to silence target gene expression. Advantageously, the modified siRNA of the present invention is less immunostimulatory than its corresponding unmodified siRNA sequence and retains RNAi activity...http://www.google.es/patents/US8101741?utm_source=gb-gplus-sharePatente US8101741 - Modified siRNA molecules and uses thereof
