A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided....http://www.google.es/patents/US6740739?utm_source=gb-gplus-sharePatente US6740739 - Substitutional variants of APO-2 ligand
