(12) UIllt€d States Patent (10) Patent N0.: US 8,082,810 B2 Moles (45) Date of Patent: Dec. 27, 2011 (54) MICROFLUIDIC ELASTIC 1 g’C0I1_I1;>1r eH11~ _ i , appne MICRO ALIQUOTTER 6,719,868 B1 4/2004 Schueller et al. _ 6,929,030 B2 8/2005 Unger et al. (75) Inventor: Donald R. Moles, Cedarv1lle, OH (US) 6,951,632 B2 10/2005 Unger et 31‘ 6,960,437 B2 11/2005 Enzelberger et al. (73) Assignee: YSI Incorporated, YelloW Springs, OH 7,040,338 B2 5/2006 Unger et al. (US) 7,077,152 B2 7/2006 Karp 7,097,809 B2 8/2006 Van Dam et al. _ _ _ _ _ 7,118,910 B2 10/2006 Unger et al. ( * ) Not1ce: Subject to any d1scla1mer, the term ofth1s 7,125,711 B2 10/2006 pugia et at patent is extended or adjusted under 35 7,275,858 B2 10/2007 Andersson et al. U_S_C_ 15403) by 340 dayS_ 7,306,672 B2 12/2007 Hansen et al. 2002/0029814 A1 3/2002 Unger et al. _ 2004/0005247 A1 1/2004 Karp (21) APPLNO" 12/240,169 2010/0254837 A1* 10/2010 Boersma etal. ......... .. 417/413.2 (22) Filed: Sep. 29, 2008 * “ted by examlner . . . Primary Examiner * Robert Raevis 65 P P bl t D t ( ) nor u lea Ion a a (74) Attorney, Agent, or Firm * Thompson Hine LLP US 2010/0077875 A1 Apr. 1, 2010 (51) I Cl (57) ABSTRACT nt. . . . . . . . . . Disclosed is a m1croflu1d1c dev1ce compns1ng at least one G01N1/14 (200601) micro-aliquotter for dispensing fixed or variable volumes. (52) U.S. Cl. .................................................. .. 73/864.34 The miCrO_a1iquOtterinC1udeS an rigid’ dimensionally Stable (58) Field of Classification Search ...................... .. None foundational layer having a fluid port therein that is in fluid See application file fOr Complete Search hiSIO1‘y- communication With a channel Within the microfluidic _ device, and an elastic film positioned on the foundational (56) References Clted layer Where the film covers the fluid port. The elastic film is
