4,111,203 9/1978 Theeuwes 128/260
4,160,020 7/1979 Ayer et al 424/15
4,186,184 1/1980 Zaffaroni 424/14
4,200,098 4/1980 Ayer et al 128/260
4,203,439 5/1980 Theeuwes et al 128/260
4,309,996 1/1982 Theeuwes 128/260
4,327,725 5/1982 Cortese et al 128/260
4,449,983 5/1984 Cortese et al 604/892
4,612,008 9/1986 Wong et al 604/892
4,800,056 1/1989 Eckenhoff et al 264/129
4,837,111 6/1989 Deters et al 424/473
4,940,465 7/1990 Theeuwes et al 604/892.1
4,971,790 11/1990 Magruder et al 424/78
5,019,396 5/1991 Ayer et al 424/473
5,021,053 6/1991 Barclay et al 604/892.1
5,057,321 10/1991 Edgren et al 424/413
5,128,145 7/1992 Edgren 424/473
Primary Examiner—Thurman K. Page
Assistant Examiner—D. Gabrielle Phelan
Attorney, Agent, or Firm—Paul L. Sabatine; Jacqueline
S. Larson; Jean M. Duvall
[57] ABSTRACT
A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floe comprising a drug, which floe, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
7 Claims, 7 Drawing Sheets
