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United States Patent [19]

Hiruma et al.

[ii] Patent Number: 4,556,057 [45] Date of Patent: Dec. 3,1985

[54] CANCER DIAGNOSIS DEVICE UTILIZING LASER BEAM PULSES

[75] Inventors: Teruo Hiruma; Atsushi Honma;

Tooru Hirano; Yutaka Tsuchiya, all
of Hamamatsu; Yoshihiro Hayata,
Tokyo; Katsuo Aizawa, Tokyo;
Harubumi Kato, Tokyo; Keiji
Kainuma, Tokyo, all of Japan

[73] Assignee:

Hamamatsu TV Co., Ltd.,

Hamamatsu, Japan

474,302 Mar. 11,1983 Foreign Application Priority Data

Appl. No.: Filed:

[21] [22] [30]

Aug. 31, 1982 [JP] Japan 57-151404

[51] Int. CI.4 A61B 6/08

[52] U.S. a 128/303.1; 128/395;

128/634; 128/654; 604/20

[58] Field of Search 128/303.1, 395, 665-667,

128/654, 634, 633, 632; 219/121 LM, 121 LE, 121 LF; 250/327.1, 458, 458.1; 351/13; 364/414; 356/138; 358/93; 604/20, 53

[56] References Cited

U.S. PATENT DOCUMENTS

4,178,917 12/1979 Shapiro 128/633

4,184,175 1/1980 Mullane, Jr 250/562

4,195,641 4/1980 Joines et al 128/632

4,213,462 7/1980 Sato 128/634

4,222,389 9/1980 Rubens 128/633

4,266,549 5/1981 Kimura 128/654

4,302,672 11/1981 Kato et al 250/337

4,310,886 1/1982 Kato et al 250/363 R

4,313,057 1/1982 Geibwachs 356/311

4,350,163 . 9/1982 Ford, Jr. et al 128/633

4,355,871 10/1982 Nevyas et al 356/376

4,396,285 8/1983 Presta et al 128/303.1

4,449,535 5/1984 Renault 128/634

4,512,762 4/1985 Spears 604/53

FOREIGN PATENT DOCUMENTS

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Cancer diagnosis device contains an endoscope comprising a light pipe used to transmit light beams from respective light sources and an image guide used to observe the flesh of the organism during both diagnosis and treatment. The tip of the endoscope faces toward the focuses where a photosensitive material having an affinity to the focuses of cancer has been absorbed so that a treatment for cancer can be performed by exposing the organism affected by cancer to the laser beam. The attainable the laser beam within a focus is thus increased by the use of the laser beam pulse from a first laser beam pulse source. In addition to the above, the cancer diagnosis device contains a second laser beam pulse source used to transmit a light beam to the focuses through the light pipe for making a diagnosis, a selector used to selectively pick up the light beam from the first laser beam pulse source or the second laser beam pulse source, a spectroscope used to obtain the spectral response from emission of light led through the image guide used for observation from the flesh of the organism where fluorescence occurs, an imaging device used to pick up the spectral response, a graphic display used to graphically display the processed spectra picked up by the imaging device, and a controller used to control emission of light from the second laser beam pulse source and also to make the operation of the imaging device synchronize with the second laser beam pulse source.

7 Claims, 11 Drawing Figures

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