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US 20060058712A1

(19) United States

(12) Patent Application Publication (io) Pub. No.: US 2006/0058712 Al

Altshuler et al. (43) Pub. Date: Mar. 16,2006

(54) METHODS AND PRODUCTS FOR

PRODUCING LATTICES OF EMR-TREATED
ISLETS IN TISSUES, AND USES THEREFOR

(75) Inventors: Gregory B. Altshuler, Wilmington, MA
(US); Ilya Yaroslavsky, North Andover,
MA (US); Andrei V. Erofeev, North
Andover, MA (US); David Tabatadze,
Worcester, MA (US); Mikhail Z.
Smirnov, Burlington, MA (US); James
J. Childs, Franklin, MA (US)

Correspondence Address:

WILMER CUTLER PICKERING HALE AND

DORR LLP

60 STATE STREET

BOSTON, MA 02109 (US)

(73) Assignee: Palomar Medical Technologies, Inc.,

Burlington, MA

(21) Appl. No.: 11/098,000

(22) Filed: Apr. 1, 2005

Related U.S. Application Data

(63) Continuation-in-part of application No. 10/465,137, filed on Jun. 19, 2003.

Continuation-in-part of application No. 10/033,302, filed on Dec. 27, 2001.

Continuation-in-part of application No. 10/080,652, filed on Feb. 22, 2002.

(60) Provisional application No. 60/561,052, filed on Apr. 9, 2004. Provisional application No. 60/614,382, filed on Sep. 29, 2004. Provisional application No. 60/620, 734, filed on Oct. 21, 2004. Provisional application No. 60/641,616, filed on Jan. 5, 2005. Provisional application No. 60/389,871, filed on Jun. 19, 2002. Provisional application No. 60/258,855, filed on Dec. 28, 2000. Provisional application No. 60/272,745, filed on Mar. 2, 2001.

Publication Classification

(51) Int. CI.

A61H 1/00 (2006.01)

(52) U.S. CI 601/15

(57) ABSTRACT

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

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