Method of mucociliary clearance in cystic fibrosis patients using alkylaryl ...

United States Patent [w]

Ghio et al.

US005830436A [ii] Patent Number: 5,830,436 [45] Date of Patent: *Nov. 3, 1998

[54] METHOD OF MUCOCILIARY CLEARANCE IN CYSTIC FIBROSIS PATIENTS USING ALKYLARYL POLYETHER ALCOHOL POLYMERS

[75] Inventors: Andrew J. Ghio; Claude A.

Piantadcsi, both of Durham, N.C.;
Thomas P. Kennedy, Richmond, Va.

[73] Assignee: Duke University, Durham, N.C.

[ * ] Notice: The term of this patent shall not extend beyond the expiration date of Pat. No. 5,474,760.

[21] Appl. No.: 413,699

[22] Filed: Mar. 30, 1995

Related U.S. Application Data

[63] Continuation-in-part of Ser. No. 219,770, Mar. 29, 1994, Pat. No. 5,474,760, which is a continuation-in-part of Ser. No. 39,732, Mar. 30, 1993, abandoned.

[51] Int. CI. A61K 9/12

[52] U.S. CI 424/45; 424/78.37; 514/851

[58] Field of Search 424/45, 78.37;

514/828, 851

[56] References Cited

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Primary Examiner—Jyothsna Venkat

Attorney, Agent, or Firm—Bell Seltzer Intellectual Property

Group of Alston & Bird, LLP

A method and medicament for the inhibition of oxidants comprising administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. Also, a method and medicament for mucociliary clearance, inhibition of cytokine production, and inhibition of interleukin-8 production in cystic fibrosis patients. The method involves administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. The medicament is preferably administered by aerosolization into the mammalian respiratory system. The medicament may also be applied to the mammalian skin. Preferably, the medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, isotonic saline, normal saline, petrolatum based ointments and U.S.P. cold cream.

5 Claims, 3 Drawing Sheets

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