Immunomodulatory polynucleotides in treatment of an infection by an ...

(54) IMMUNOMODULATORY

POLYNUCLEOTIDES IN TREATMENT OF
AN INFECTION BY AN INTRACELLULAR
PATHOGEN

(75) Inventors: Eyal Raz, Del Mar, CA (US); Richard
Kornbluth, La Jolla, CA (US); Antonio
Catanzaro, San Diego, CA (US);
Tomoko Hayashi, San Diego, CA (US);
Dennis Carson, Del Mar, CA (US)

(73) Assignees: The Regents of the University of California, Oakland, CA (US); The United States of America as represented by the Department of Veteran Affairs, Washington, DC (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 32 days.

(21) Appl. No.: 09/774,403

(22) Filed: Jan. 30, 2001

(65) Prior Publication Data

US 2002/0086295 Al Jul. 4, 2002

Related U.S. Application Data

(60) Provisional application No. 60/179,353, filed on Jan. 31, 2000.

(51) Int. CI. A61P 37/06

(52) U.S. CI 514/44; 435/320.1; 536/23.1

Romano et al., Latest developments in gene transfer technology: Achievements, perspectives and controversies over therapeutic applications, 2000, Stem Cells, vol. 18, pp. 19-39.*

Krieg, Direct immunologic activities of CpG DNA and implications for gene therapy, 1999, The Journal of Gene Medicine, vol. 1, pp. 56-63.*

Tokunaga et al., How BCG to the discovery of immunostimulatory DNA, 1999, Japan J. Infect. Dis., vol. 52, pp. 1-11.*

Orkin et al., Report and recommendations of the panel to assess the NIH investment in research on gene therapy, 1995, NIH,pp. 1-33.*

Kmiec, Gene therapy, 1999, American Scientist, vol. 87, pp. 240-247.*

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(List continued on next page.)

Primary Examiner—James Ketter

Assistant Examiner—Daniel M. Sullivan

(74) Attorney, Agent, or Firm—Carol L. Francis; Paula A.

Borden; Bozicevic, Field & Francis, LLP

OTHER PUBLICATIONS

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* cited by examiner