United States Patent [19] [ii] Patent Number: 4,610,847
Hood et al. [45] Date of Patent: Sep. 9,1986
[54] CONVERSION FLASK FOR SEQUENTIAL PERFORMANCE APPARATUS
[75] Inventors: Leroy E. Hood, Pasadena; Michael W. Hunkapiller, San Gabriel; William J. Dreyer, Pasadena; Rodney M. Hewick, Pasadena; Anton W. Stark, Pasadena, all of Calif.
[73] Assignee: California Institute of Technology, Pasadena, Calif.
[21] Appl. No.: 602,699
[22] Filed: Apr. 23, 1984
Related U.S. Application Data
[62] Division of Ser. No. 380,109, May 20, 1982, which is a division of Ser. No. 190,100, Sep. 23, 1980, abandoned.
[51] Int. CI.4 B01J 19/26; G01N 33/68
[52] U.S. CI 422/102; 261/124;
422/68; 422/231; 436/89
[58] Field of Search 422/102, 231, 68;
261/124; 239/524, 267; 436/89, 174
[56] References Cited
U.S. PATENT DOCUMENTS
3,959,307 5/1976 Wittmann-Liebold et al. .
4,065,412 12/1977 Dreyer .
4,134,514 1/1979 Shumacher et al 261/124 X
4,227,886 10/1980 Bullock et al 422/64 X
OTHER PUBLICATIONS
Wittmann-Liebold et al(II), Analytical Biochemistry,
vol. 75, pp. 621-633, 1976, "A Device Coupled to a
Modified Sequenator for the Automated Conversion of
Anilinothiazolinones into PTH Amino Acids".
Primary Examiner—Arnold Turk
Attorney, Agent, or Firm—Joseph E. Mueth
[57] ABSTRACT
Conversion flask for use is an apparatus for the sequential performance of chemical processes on a sample of chemical material. The flask includes at least three capillary tubes and a large bore tube extending into the interior thereof for the introduction and withdrawal of various fluids. The capillary tubes are constructed to introduce a plurality of fine bubbles into a liquid within the flask to agitate the liquid and accelerate drying, to impinge chemicals on the walls of the flask, and to produce a spray onto the interior walls of the flask in proximity to its upper end to wash down the interior walls of the flask.
1,532,233 4/1925 Dahlberg et al. 1,595,626 8/1926 Gunther et al.
6 Claims, 27 Drawing Figures
