Transdermal delivery device

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(12) United States Patent

Cleary et al.

(io) Patent No.: (45) Date of Patent:

US 7,611,481 B2 Nov. 3, 2009

(54) TRANSDERMAL DELIVERY DEVICE

(75) Inventors: Gary W. Cleary, Los Altos Hills, CA

(US); Steven R. Klemm, Grand Rapids,
MI (US)

(73) Assignee: Corium International, Inc., Menlo
Park, CA (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 312 days.

(21) Appl.No.: 11/088,829

(22) Filed: Mar. 24, 2005

(65) Prior Publication Data

US 2005/0228340 Al Oct. 13, 2005

Related U.S. Application Data

(60) Provisional application No. 60/555,841, filed on Mar. 24, 2004.

(51) Int. CI.

A61B 17/20 (2006.01)

(52) U.S. CI 604/46; 604/27; 604/87;

604/289; 604/290; 604/310; 604/890.1

(58) Field of Classification Search 604/890.1,

604/891.1, 892.1, 1-3, 19-22, 46-48, 502, 604/87, 93.01, 115, 180, 181, 183, 191, 239, 604/244, 272, 289, 306, 307, 308, 27, 310 See application file for complete search history.

(56) References Cited

4,402,696 A 9/1983 Gulko

4,460,368 A 7/1984 Allison etal.

4,460,370 A 7/1984 Allison etal.

4,556,441 A 12/1985 Faasse, Jr.

4,597,961 A 7/1986 Etscorn

4,743,249 A 5/1988 Loveland

4,812,305 A 3/1989 Vocal

4,904,475 A 2/1990 Gale etal.

5,051,259 A 9/1991 Olsenetal.

5,061,258 A * 10/1991 Martz 604/307

5,160,315 A 11/1992 Heinecke et al.

5,244,677 A 9/1993 Kreckel et al.

5,250,023 A * 10/1993 Lee etal 604/20

5,308,625 A 5/1994 Wong etal.

5,330,452 A 7/1994 Zook

5,462,743 A 10/1995 Turner etal.

5,476,443 A * 12/1995 Cartmell et al 602/58

5,503,843 A * 4/1996 Santusetal 424/448

5,520,629 A 5/1996 Heinecke et al.

5,531,855 A 7/1996 Heinecke et al.

5,730,721 A 3/1998 Hyatt etal.

(Continued)

Primary Examiner—Nicholas D Lucchesi

Assistant Examiner—Quynh-Nhu H Vu

(74) Attorney, Agent, or Firm—Flavio M. Rose; Mintz,

Levin, Cohn, Ferris, Glovsky and Popeo, PC

(57) ABSTRACT

A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

23 Claims, 8 Drawing Sheets