(22) Filed: Jan. 22, 2008 (65) Prior Publication Data US 2008/0208107 A1 Aug. 28, 2008
Related U.S. Application Data
(63) Continuation-in-part of application No. 10/384,763, filed on Mar. 11, 2003, now abandoned.
(60) Provisional application No. 60/886,039, filed on Jan. 22, 2007, provisional application No. 60/363,022, filed on Mar. 11, 2002.
(51) Int. Cl. A61F 13/02 (2006.01) A61N 1/30 (2006.01)
(52) U.S. Cl. ........................................ .. 604/20; 604/307 (58) Field of Classification Search .................. .. 604/20, 604/200, 307, 573, 22, 304, 306, 308, 289; 424/449, 448, 447, 443; 602/2, 3,48, 41
See application file for complete search history.
(56) References Cited U.S. PATENT DOCUMENTS 2,893,392 A 7/1959 Alan (Continued)
FOREIGN PATENT DOCUMENTS EP 0 497 620 8/1992 (Continued)
“After bite’s unique formula key to efficacy” news release (no author), Tender Corporation, Littleton, NH, Aug. 1994.
Primary Examiner 4 Tan-Uyen (Jackie) T. Ho Assistant Examiner 4 Michael J Anderson (74) Attorney, Agent, or Firm 4 King & Spalding LLP
A transdermal perrneant delivery system for delivery of at least one perrneant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
92 Claims, 26 Drawing Sheets
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