Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage ...

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United States Patent m

Sekins et al.

US005562608A [ii] Patent Number: [45] Date of Patent:

5,562,608 Oct. 8, 1996

[54] APPARATUS FOR PULMONARY DELIVERY OF DRUGS WITH SIMULTANEOUS LIQUID LAVAGE AND VENTDLATION

[75] Inventors: K. Michael Sekins, San Diego, Calif.;

Thomas H. Shaffer, Lansdowne;
Maria R. Wolfson, Wyndmoor, both of
Pa.

[73] Assignees: BioPulmonics, Inc., Redmond, Wash.;

Temple University, Philadelphia, Pa.

[21] Appl. No.: 424,577

[22] Filed: Apr. 13, 1995

Related U.S. Application Data

[63] Continuation of Ser. No. 920,153, Jul. 27, 1992, abandoned, which is a continuation of Ser. No. 495,566, published as PCTAJS89/04035, Sep. 15, 1989, abandoned, which is a continuation-in-part of Ser. No. 399,943, Aug. 28, 1989, abandoned.

[51] Int. CI.6 A61N 1/30

[52] U.S. CI 604/20; 128/207.15; 128/898

[58] Field of Search 604/19, 20; 128/200.14,

128/200.18, 200.21, 203.12, 200.24, 207.14, 207.15, 207.16, 898; 404/83

[56] References Cited

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4,881,542 11/1989 Schmidt et al 128/207.14

4,889,525 12/1989 Yuhas et al 600/1

4,955,375 11/1990 Martinez 128/207.14

4,976,261 12/1990 Gluck et al 128/207.14

5,031,613 7/1991 Smith et al 128/207.14

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(List continued on next page.)

Primary Examiner—C. Fred Rosenbaum
Assistant Examiner—Chalin Smith

Attorney, Agent, or Firm—Knobbe, Martens, Olson & Bear

OTHER PUBLICATIONS

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