(12) United States Patent
Thorpe et al.
US006261535B1
(io) Patent No.: US 6,261,535 Bl (45) Date of Patent: *Jul. 17,2001
(54) DIAGNOSTIC METHODS FOR TARGETING THE VASCULATURE OF SOLID TUMORS
(75) Inventors: Philip E. Thorpe, Dallas, TX (US);
Francis J. Burrows, San Diego, CA
(US)
(73) Assignee: The University of Texas System
Board of Regents, Austin, TX (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
This patent is subject to a terminal disclaimer.
(21) Appl. No.: 09/207,277
(22) Filed: Dec. 8, 1998
Related U.S. Application Data
(63) Continuation of application No. 08/350,212, filed on Dec. 5, 1994, now Pat. No. 5,965,132, which is a continuation-inpart of application No. 08/205,330, filed on Mar. 2, 1994, now Pat. No. 5,855,866, which is a continuation-in-part of application No. 07/846,349, filed on Mar. 5, 1992.
(51) Int. CI.7 A61K 51/10; A61K 39/395;
C07K 16/00
(52) U.S. CI 424/1.49; 424/1.49; 424/9.32;
424/9.341; 424/9.36; 424/178.1; 424/179.1; 424/9.42; 424/186.1; 424/130.1; 424/133.1; 424/183.1; 424/142.1; 424/145.1; 424/181.1; 424/155.1; 424/9.34; 424/9.323; 424/156.1; 530/391.7; 530/391.3; 530/388.1; 530/388.15;
530/388.22; 530/387.1
(58) Field of Search 424/1.49, 178.1,
424/9.32, 9.341, 9.34, 9.323, 179.1, 156.1, 183.1, 142.1, 9.36, 9.42; 530/387.1, 388.1, 388.22, 388.15, 391.3
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Primary Examiner—Diana Dudash
Assistant Examiner—Shahnam Sharareh
(74) Attorney, Agent, or Firm—-Williams, Morgan and
Amerson
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