[54] CHEMOTACTIC WOUND HEALING PEPTIDES
[76] Inventors: Arnold E. Postlethwaite, 635 Bethany Rd., Eads, Tenn. 38028; Jerome Seyer, 1412 Carr Ave., Memphis, Tenn. 38104; Andrew Kang, 2334 Massey Rd., Memphis, Tenn. 38119
[ * ] Notice: The term of this patent shall not extend beyond the expiration date of Pat. No. 5,436,228.
[21] Appl. No.: 457,353
[22] Filed: Jun. 1, 1995
Related U.S. Application Data
[63] Continuation-in-part of Ser. No. 127,909, Sep. 28,1993, Pat. No. 5,436,228, which is a continuation-in-part of Ser. No. 626,631, Dec. 12, 1990, abandoned.
[51] Int. CI.6 A61K 38/00; A61K 38/04;
C07K 5/00; C07K 7/00
[52] U.S. CI 514/13; 514/12; 514/17;
530/324; 530/326; 530/329
[58] Field of Search 530/324, 326,
530/329; 514/12, 13, 17
[56] References Cited
U.S. PATENT DOCUMENTS
4,806,523 2/1989 Bentz et al 514/2
4,971,952 11/1990 Bentz et al 514/12
5,008,240 4/1991 Bentz et al 514/2
5,061,786 10/1991 Burnier et al 530/326
5,104,977 4/1992 Sporn et al 530/399
5,436,228 7/1995 Postlethwaite et al 514/12
FOREIGN PATENT DOCUMENTS
0542679 5/1993 European Pat. Off. .
2-152988 8/1988 Japan .
US90/05091 3/1991 WIPO .
US90/06006 5/1991 WIPO .
OTHER PUBLICATIONS
Border et al., 1992 Transforming Growth Factor-|3 Disease: The Dark Side of Tissue Repair. /. Clin. Invest., 90:1-7. Davidson, J.M., 1992 Wound Repair. Inflammation: Basic Principles and Clinical Correlates, 2d ed., J.I. Gallin, I.M. Goldstein and R. Snyderman, eds., Raven Press, Ltd., New York.
Flanders et al., 1988 Antibodies to Peptide Determinants in Transforming Growth Factor (3 and Their Applications. Biochem. 27:739-746.
Massague et al., 1992 Transforming Growth Factor-|3. Cancer Surveys vol. 12: Tumour Suppressor Genes, the Cell Cycle and Cancer, pp. 81-103.
Postlethwai et al., 1992 Identification of Chemotactic Epitopes of Transforming Growth Factor (TGF) -(31. Arthritis and Rhumatism vol. 35, No. 9, Supplement (Abstract A62).
Postlethwaite, A., 1993 Stimulation of Elevated Levels of IL-1P Protein and IL-1|3 mRNA by Synthetic TGF-|31 Peptide, 337-374. ACR 57th Annual Scientific Meeting, San Antonio, Texas (Abstract).
Postlethwaite et al., 1987 Stimulation of the Chemotactic
Migration of Human Fibroblasts by Transforming Growth
Factor |3./. Exper. Med., 165: 251-256.
Sasaki et al., 1992 Transforming Growth Factor-|3 in the
Regulation of the Immune Response. Clinical Immunology
and Immunopathology. vol. 65, 1: 1-9.
Duke et al. (1988) "Identification of another member of the
transforming Growth Factor Type (3 Gene Family", Pro.
Nat'l. Acad. Scl, USA, 85: 4715-4719.
Kondaiah et al., (1990) Identification of a Novel Tranform
ing Growth Factor-(32 (TGF-(32 from /. Biol. Chem. 265:
1089-1093.
Jakowlew et al., (1988) "Complementary Deoxyribonucleic
Acid Cloning of a Messenger Ribonucleic Acid Encoding
Transforming Growth Factor-(34 from Children Embryo
Chondroaytes" Mol. Endocrinol, 2: 1186-1195.
Marguardt et al., (1987) "Complete Amino Acid Sequence
of Human Transforming Growth Factors Type |32 ", J. Biol.
Chem., 262: 12127-12131.
Primary Examiner—Cecilia J. Tsang
Assistant Examiner—-Jennifer Harle
Attorney, Agent, or Firm—Scully, Scott, Murphy & Presser
